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Post-translational modifications in tumor-associated carbonic anhydrases
Anna Di Fiore1, Claudiu T Supuran2, Andrea Scaloni3
1Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, 80134, Napoli, Italy.
Amino Acids
|August 26, 2021
Summary
Human carbonic anhydrases IX and XII (hCA IX and hCA XII) are key in tumor development. This review details their post-translational modifications (PTMs) and roles in cancer pathology.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Human carbonic anhydrases IX (hCA IX) and XII (hCA XII) are implicated in tumor progression.
- Previous research focused on biochemical and functional aspects of hCA IX and hCA XII.
- Limited information exists on the post-translational modifications (PTMs) of these enzymes and their impact in tumors.
Purpose of the Study:
- To review and summarize the existing literature on PTMs of hCA IX and hCA XII.
- To highlight the functional implications of these PTMs in the tumor microenvironment.
- To connect specific PTMs to cancer pathological processes.
Main Methods:
- Literature review of existing studies on hCA IX and hCA XII.
- Compilation of data on identified post-translational modifications.
- Analysis of functional roles and cancer relevance of PTMs.
Main Results:
- Summarized known PTMs for hCA IX and hCA XII, including disulphide bond formation, phosphorylation, glycosylation (O- and N-linked), acetylation, and ubiquitination.
- Identified specific roles for certain PTMs in cancer development and progression.
- Highlighted gaps in current knowledge regarding PTM characterization and functional impact.
Conclusions:
- Post-translational modifications significantly influence the function of hCA IX and hCA XII in cancer.
- Further research is needed to fully elucidate the PTM landscape and functional consequences of hCA IX and hCA XII in tumors.
- Understanding these PTMs could offer new therapeutic strategies for cancer treatment.
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