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Post-translational modifications in tumor-associated carbonic anhydrases

Anna Di Fiore1, Claudiu T Supuran2, Andrea Scaloni3

  • 1Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, 80134, Napoli, Italy.

Amino Acids
|August 26, 2021
PubMed

Insights

Human carbonic anhydrases IX and XII (hCA IX and hCA XII) are key in tumor development. This review details their post-translational modifications (PTMs) and roles in cancer pathology.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Human carbonic anhydrases IX (hCA IX) and XII (hCA XII) are implicated in tumor progression.
  • Previous research focused on biochemical and functional aspects of hCA IX and hCA XII.
  • Limited information exists on the post-translational modifications (PTMs) of these enzymes and their impact in tumors.

Purpose of the Study:

  • To review and summarize the existing literature on PTMs of hCA IX and hCA XII.
  • To highlight the functional implications of these PTMs in the tumor microenvironment.
  • To connect specific PTMs to cancer pathological processes.

Main Methods:

  • Literature review of existing studies on hCA IX and hCA XII.
  • Compilation of data on identified post-translational modifications.
  • Analysis of functional roles and cancer relevance of PTMs.

Main Results:

  • Summarized known PTMs for hCA IX and hCA XII, including disulphide bond formation, phosphorylation, glycosylation (O- and N-linked), acetylation, and ubiquitination.
  • Identified specific roles for certain PTMs in cancer development and progression.
  • Highlighted gaps in current knowledge regarding PTM characterization and functional impact.

Conclusions:

  • Post-translational modifications significantly influence the function of hCA IX and hCA XII in cancer.
  • Further research is needed to fully elucidate the PTM landscape and functional consequences of hCA IX and hCA XII in tumors.
  • Understanding these PTMs could offer new therapeutic strategies for cancer treatment.
Keywords:
Carbonic anhydrase IXCarbonic anhydrase XIIDrug designPost-translational modifications

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