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Updated: Oct 22, 2025

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
55-year-old Male with Fatigue
Jennifer Nichols1, Jennifer Guyther2, Laura J Bontempo2
1University of Maryland Medical Center, Department of Emergency Medicine, Baltimore, Maryland.
A case study details the emergency assessment of a dialysis patient with fatigue, highlighting diagnostic reasoning. The surprising final diagnosis underscores the importance of a thorough differential diagnosis in emergency medicine.
Area of Science:
- Clinical Medicine
- Emergency Medicine
- Nephrology
Background:
- Fatigue is a common presenting complaint in emergency departments.
- Patients with end-stage renal disease requiring dialysis are particularly susceptible to various complications.
- Effective differential diagnosis is crucial for timely and accurate patient management.
Purpose of the Study:
- To present a clinicopathological case of a 55-year-old dialysis-dependent male with fatigue.
- To illustrate the thought process of an emergency medicine physician in developing a differential diagnosis for fatigue.
- To detail the diagnostic workup and reveal a surprising final diagnosis.
Main Methods:
- Case presentation methodology.
- Description of the emergency physician's differential diagnosis development process.
- Review of diagnostic tests employed to confirm the suspected diagnosis.
Main Results:
- Detailed account of the initial assessment and management strategies.
- Explanation of the clinical reasoning leading to the suspected diagnosis.
- Identification of specific tests utilized for diagnostic confirmation.
Conclusions:
- The case highlights a challenging presentation of fatigue in a dialysis-dependent patient.
- Demonstrates a systematic approach to differential diagnosis in emergency medicine.
- The surprising final diagnosis emphasizes the need for comprehensive evaluation beyond common etiologies.
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