Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fatigue01:21

Fatigue

295
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
295
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

97
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
97
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

3.2K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
3.2K
Menopause01:28

Menopause

2.5K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
2.5K
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

84
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
84
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

76
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
76

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

19-month-old Girl with Seizure.

Clinical practice and cases in emergency medicine·2026
Same author

Harnessing the murine inner cell mass mechanical environment enhances derivation of in vitro nascent primitive endoderm precursor cells.

Development (Cambridge, England)·2026
Same author

The authors' responses: "Reader comment regarding prophylactic antibiotics for immunosuppressed individuals with anterior nasal packing: A propensity score matching study".

The American journal of emergency medicine·2026
Same author

Interpreting Fentanyl and Norfentanyl Concentrations among Patients Seen in the Emergency Department after a Nonfatal Opioid Overdose: A Multicenter Study.

Journal of medical toxicology : official journal of the American College of Medical Toxicology·2026
Same author

Correction: Tracking early mammalian organogenesis - prediction and validation of differentiation trajectories at whole organism scale.

Development (Cambridge, England)·2026
Same author

70-year-old Woman with Chest Tightness and Shortness of Breath.

Clinical practice and cases in emergency medicine·2026

Related Experiment Video

Updated: Oct 22, 2025

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.3K

55-year-old Male with Fatigue.

Jennifer Nichols1, Jennifer Guyther2, Laura J Bontempo2

  • 1University of Maryland Medical Center, Department of Emergency Medicine, Baltimore, Maryland.

Clinical Practice and Cases in Emergency Medicine
|August 26, 2021
PubMed
Summary
This summary is machine-generated.

A case study details the emergency assessment of a dialysis patient with fatigue, highlighting diagnostic reasoning. The surprising final diagnosis underscores the importance of a thorough differential diagnosis in emergency medicine.

More Related Videos

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
04:24

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

355
Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.0K

Related Experiment Videos

Last Updated: Oct 22, 2025

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.3K
Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
04:24

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

355
Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.0K

Area of Science:

  • Clinical Medicine
  • Emergency Medicine
  • Nephrology

Background:

  • Fatigue is a common presenting complaint in emergency departments.
  • Patients with end-stage renal disease requiring dialysis are particularly susceptible to various complications.
  • Effective differential diagnosis is crucial for timely and accurate patient management.

Purpose of the Study:

  • To present a clinicopathological case of a 55-year-old dialysis-dependent male with fatigue.
  • To illustrate the thought process of an emergency medicine physician in developing a differential diagnosis for fatigue.
  • To detail the diagnostic workup and reveal a surprising final diagnosis.

Main Methods:

  • Case presentation methodology.
  • Description of the emergency physician's differential diagnosis development process.
  • Review of diagnostic tests employed to confirm the suspected diagnosis.

Main Results:

  • Detailed account of the initial assessment and management strategies.
  • Explanation of the clinical reasoning leading to the suspected diagnosis.
  • Identification of specific tests utilized for diagnostic confirmation.

Conclusions:

  • The case highlights a challenging presentation of fatigue in a dialysis-dependent patient.
  • Demonstrates a systematic approach to differential diagnosis in emergency medicine.
  • The surprising final diagnosis emphasizes the need for comprehensive evaluation beyond common etiologies.