Orthopaedic Gene Therapy: Twenty-Five Years On.

Area of Science:

• Orthopaedic gene therapy research.
• Regenerative medicine applications.

Background:

• Gene therapy is moving beyond rare single-gene disorders.
• Orthopaedics is a key area for gene therapy expansion.

Purpose of the Study:

• To explore current and potential orthopaedic applications of gene therapy.
• To highlight the potential for broader access to gene therapies.

Main Methods:

• Review of existing gene therapy applications in orthopaedics.
• Discussion of ongoing clinical trials for arthritis and regenerative medicine.
• Identification of future therapeutic targets within orthopaedics.

Main Results:

• Gene therapy for osteoarthritis (Invossa) faced regulatory challenges but is under renewed investigation.
• Multiple clinical trials are underway for gene therapies targeting arthritis.
• Research is active in bone healing, cartilage repair, and other musculoskeletal conditions.

Conclusions:

• Orthopaedics offers a significant frontier for gene therapy development.
• Successful gene therapies in this field could lead to more accessible treatments.
• Further research and clinical trials are crucial for realizing the potential of gene therapy in orthopaedics.