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Updated: Oct 22, 2025

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
Percutaneous Closure of a Cribriform Secundum Atrial Septal Defect and Patent Foramen Ovale
Jeffrey Wilson1, Mansi Oberoi2, Tom Stys1
1Sanford Cardiovascular Institute, Sioux Falls, South Dakota.
Insights
Atrial septal defects and patent foramen ovale increase stroke risk. A novel "sandwich technique" successfully closed a complex ASD and PFO percutaneously using two devices.
Area of Science:
- Cardiology
- Interventional Cardiology
- Congenital Heart Disease
Background:
- Atrial septal defects (ASDs) and patent foramen ovale (PFO) are prevalent congenital heart conditions.
- These defects are associated with an elevated risk of ischemic stroke.
- Surgical intervention for ASDs carries significant risks.
Observation:
- A patient presented with a symptomatic cribriform secundum ASD and coexisting PFO.
- The defect anatomy was complex, posing a challenge for standard closure methods.
Findings:
- Successful percutaneous closure of the complex ASD and PFO was achieved.
- Two Amplatzer occluder devices were utilized in a novel
Implications:
- Percutaneous closure is a safe and effective alternative to surgery for ASDs and PFOs.
- The "sandwich technique" offers a viable solution for complex defects.
- This approach may reduce stroke risk in patients with these cardiac malformations.
Abstract:
Atrial septal defects (ASDs) and patent foramen ovale (PFO) are common congenital cardiac malformations that portend a higher risk of ischemic stroke. Percutaneous closure of ASDs using septal occluder devices has proven to be a safe and effective alternative to surgery. We present a case of symptomatic cribriform secundum ASD and PFO who underwent successful percutaneous closure using two Amplatzer occluder devices using a novel "sandwich technique."
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