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Related Experiment Video

Updated: Oct 22, 2025

Image Acquisition using Portable Sonography for Emergency Airway Management
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Image Acquisition using Portable Sonography for Emergency Airway Management

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MIS-C-Implications for the Pediatric Surgeon: An Algorithm for Differential Diagnostic Considerations.

Nora Manz1,2, Claudia Höfele-Behrendt1, Julia Bielicki3

  • 1Department of Pediatric Surgery, University Children's Hospital Basel, 4056 Basel, Switzerland.

Children (Basel, Switzerland)
|August 27, 2021
PubMed
Summary

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Multisystem inflammatory syndrome in children (MIS-C), a condition linked to SARS-CoV-2, can mimic surgical emergencies. Early recognition and surgical consideration are crucial for timely diagnosis and treatment of MIS-C.

Area of Science:

  • Pediatric Surgery
  • Infectious Diseases
  • Pediatric Critical Care

Background:

  • Multisystem inflammatory syndrome in children (MIS-C) is a novel disease associated with SARS-CoV-2 infection.
  • MIS-C can present with abdominal symptoms, fever, and elevated inflammatory markers, mimicking surgical conditions.

Purpose of the Study:

  • To highlight MIS-C as a critical differential diagnosis in pediatric surgical emergencies.
  • To emphasize the importance of clinical history and surveillance in diagnosing MIS-C.

Main Methods:

  • Retrospective review of clinical data from three pediatric patients with MIS-C who underwent surgery.
  • Histopathological analysis of appendiceal specimens.

Main Results:

Keywords:
PIMS-TSSARS-CoV-2acute abdomendifferential diagnosis of appendicitismultisystem inflammatory syndrome in childrenpediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2pediatric surgery

Related Experiment Videos

Last Updated: Oct 22, 2025

Image Acquisition using Portable Sonography for Emergency Airway Management
07:31

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  • Three children presented with fever, abdominal pain, and vomiting, leading to surgical intervention (appendectomy in two).
  • All patients were diagnosed with MIS-C postoperatively and treated with immunomodulatory and anticoagulant therapies.

    • Conclusions:

    • MIS-C should be considered in the differential diagnosis of acute abdomen in children.
    • An algorithm is proposed for pediatric surgeons to integrate MIS-C evaluation into their workflow.