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Updated: Oct 22, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer

Kanika Singh1, Nazim Nassar2, Ava Bachari1

  • 1The Pangenomics Lab, School of Science, RMIT University, Bundoora, VIC 3083, Australia.

Cancers
|August 27, 2021
PubMed

Insights

Cannabinoids show promise in regulating cell growth and may offer new antitumor drugs for prostate cancer treatment. Further research into their mechanisms could lead to novel therapeutic strategies.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Prostate cancer is a leading cancer diagnosis in males globally.
  • Cannabinoids are increasingly recognized for their potential roles in regulating cell growth and differentiation.
  • Existing research suggests cannabinoids possess palliative effects and antitumor properties across various cancers.

Purpose of the Study:

  • To review preclinical evidence on the anticancer effects of cannabinoids in prostate cancer.
  • To explore the potential mechanisms of action through which cannabinoids exert antitumor effects.
  • To provide pharmacological insights for developing cannabinoid-based prostate cancer therapies.

Main Methods:

  • Systematic review of preclinical studies.
  • Analysis of research on cannabinoid mechanisms in prostate cancer.
  • Pharmacological evaluation of cannabinoid compounds.

Main Results:

  • Cannabinoids demonstrate significant potential as antitumor agents against prostate cancer.
  • Multiple mechanisms of action are implicated in cannabinoid-induced cancer cell regulation.
  • Evidence supports cannabinoid efficacy beyond palliative care.

Conclusions:

  • Cannabinoids show promise as a novel therapeutic approach for prostate cancer.
  • Understanding specific cannabinoid mechanisms can guide the development of targeted antitumor drugs.
  • Further investigation is warranted to translate preclinical findings into clinical applications for prostate cancer treatment.
Keywords:
cancercannabinoid receptorscannabinoidscannabisprostate cancer

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