Related Experiment Video

Updated: Oct 22, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Relevance of BET Family Proteins in SARS-CoV-2 Infection

Nieves Lara-Ureña1, Mario García-Domínguez1

  • 1Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER), CSIC-Universidad de Sevilla-Universidad Pablo de Olavide, Av. Américo Vespucio 24, 41092 Seville, Spain.

Biomolecules
|August 27, 2021
PubMed

Insights

The SARS-CoV-2 virus

Area of Science:

  • Virology
  • Molecular Biology
  • Drug Discovery

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has had a devastating global impact.
  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes host cell machinery for replication.
  • Bromodomain and Extra Terminal domain (BET) proteins are crucial for cellular processes including inflammation and immune response.

Purpose of the Study:

  • To investigate the interaction between SARS-CoV-2 proteins and host cell factors.
  • To explore the potential of targeting BET proteins for therapeutic intervention against SARS-CoV-2 infection.

Main Methods:

  • Proteomic analysis to identify viral protein interactions.
  • Investigation of BET protein involvement in viral propagation.
  • Evaluation of BET inhibitors in preclinical models of SARS-CoV-2 infection.

Main Results:

  • Proteomic analysis revealed that the SARS-CoV-2 E protein interacts with BET proteins (BRD2 and BRD4).
  • BET proteins play a fundamental role in transcription, making them key targets for viral propagation.
  • BET inhibitors have shown promising results in preclinical studies against SARS-CoV-2.

Conclusions:

  • The interaction between SARS-CoV-2 E protein and BET proteins presents a novel therapeutic target.
  • BET inhibitors demonstrate potential as a treatment strategy for COVID-19.
  • Further research into BET protein inhibition could lead to effective antiviral therapies.

Keywords:
BETBET inhibitorsBRD2BRD4COVID-19SARS-CoV-2immunityinflammationvirus

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