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Serum Chemerin Concentration Is Associated with Proinflammatory Status in Chronic Coronary Syndrome

Anna Szpakowicz1, Malgorzata Szpakowicz2, Magda Lapinska2

  • 1Department of Cardiology, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Białystok, Poland.

Biomolecules
|August 27, 2021
PubMed

Insights

Chemerin levels in coronary artery disease (CAD) patients correlate with inflammation and insulin resistance. Its link to fat mass varies with glucose metabolism, suggesting different regulation mechanisms.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Chemerin, an adipokine and chemoattractant, is elevated in coronary artery disease (CAD).
  • Understanding chemerin's associations with metabolic and body composition markers is crucial in CAD patients.

Purpose of the Study:

  • To investigate the associations between serum chemerin levels and biochemical measurements.
  • To explore the relationship between chemerin and body composition in patients with stable CAD.

Main Methods:

  • Study included 163 patients with stable CAD post-percutaneous coronary intervention (PCI).
  • Serum chemerin, insulin, and c-peptide levels were measured.
  • Body composition was assessed using DEXA; biochemical markers were analyzed.

Main Results:

  • Chemerin positively correlated with white blood cell count, neutrophil-to-lymphocyte ratio, hsCRP, lipid profiles, triglycerides, platelets, fasting insulin, and c-peptide.
  • No significant difference in chemerin levels was found between diabetic and non-diabetic patients.
  • Chemerin correlated with total fat mass only in patients with normal glucose metabolism.

Conclusions:

  • Serum chemerin levels in CAD patients are linked to inflammation, insulin resistance, and dyslipidemia.
  • The association between chemerin and fat mass is contingent on glucose metabolism status.
  • Chemerin secretion regulation may differ based on diabetes or prediabetes presence.
Abstract

Keywords:
body compositionchemerincoronary artery diseaseinsulin resistanceneutrophil to lymphocyte ratiowhite blood cells count

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