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Updated: Oct 22, 2025
Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
Published on: January 10, 2019
Clinical Perspectives of Single-Cell RNA Sequencing
Nayoung Kim1,2, Hye Hyeon Eum1,2, Hae-Ock Lee1,2
1Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Abstract:
The ability of single-cell genomics to resolve cellular heterogeneity is highly appreciated in cancer and is being exploited for precision medicine. In the recent decade, we have witnessed the incorporation of cancer genomics into the clinical decision-making process for molecular-targeted therapies. Compared with conventional genomics, which primarily focuses on the specific and sensitive detection of the molecular targets, single-cell genomics addresses intratumoral heterogeneity and the microenvironmental components impacting the treatment response and resistance. As an exploratory tool, single-cell genomics provides an unprecedented opportunity to improve the diagnosis, monitoring, and treatment of cancer. The results obtained upon employing bulk cancer genomics indicate that single-cell genomics is at an early stage with respect to exploration of clinical relevance and requires further innovations to become a widely utilized technology in the clinic.
Insights
Single-cell genomics offers insights into cancer
Area of Science:
- Oncology
- Genomics
- Precision Medicine
Background:
- Single-cell genomics is crucial for understanding cancer's cellular heterogeneity.
- Cancer genomics is increasingly integrated into clinical decisions for targeted therapies.
Purpose of the Study:
- To explore the clinical relevance and potential of single-cell genomics in cancer care.
- To compare single-cell genomics with conventional genomics in addressing tumor complexity.
Main Methods:
- Utilizing single-cell genomics to analyze intratumoral heterogeneity.
- Investigating microenvironmental factors influencing cancer treatment response and resistance.
Main Results:
- Single-cell genomics reveals intratumoral heterogeneity and microenvironmental impacts.
- This technology offers new avenues for cancer diagnosis, monitoring, and treatment.
Conclusions:
- Single-cell genomics holds significant promise for advancing precision oncology.
- Further innovation is needed for widespread clinical adoption of single-cell genomics in cancer treatment.
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