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The Role of Galectin-3 and ST2 in Cardiology: A Short Review

Ana Merino-Merino1, Jeronimo Gonzalez-Bernal2, Dario Fernandez-Zoppino2,3

  • 1Department of Cardiology, University Hospital of Burgos, 09005 Burgos, Spain.

Biomolecules
|August 27, 2021
PubMed

Insights

Galectin-3 and ST2 are key biomarkers in heart failure. Novel evidence links these cardiac biomarkers to coronary heart disease and atrial fibrillation, suggesting broader diagnostic and prognostic roles.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Molecular Biology

Background:

  • Galectin-3, a beta-galactoside-binding lectin, mediates cardiac remodeling and fibrosis via macrophage and fibroblast activation.
  • ST2 is released by myocardial cells under cardiac overload, commonly used in heart failure management.
  • Traditional roles of galectin-3 and ST2 focus on heart failure therapy guidance and disease progression monitoring.

Purpose of the Study:

  • To review the diagnostic and prognostic significance of galectin-3 and ST2.
  • To explore the emerging roles of these biomarkers in coronary heart disease and atrial fibrillation.

Main Methods:

  • Literature review of studies investigating galectin-3 and ST2.
  • Analysis of diagnostic and prognostic data in various cardiac conditions.
  • Synthesis of current evidence on biomarker roles.

Main Results:

  • Galectin-3 and ST2 are established in heart failure.
  • Emerging data indicate a connection between galectin-3, ST2, and atrial fibrillation.
  • These biomarkers show potential beyond heart failure management.

Conclusions:

  • Galectin-3 and ST2 possess significant diagnostic and prognostic value in cardiovascular diseases.
  • Their roles extend to conditions like atrial fibrillation, warranting further investigation.
  • Understanding these biomarkers can refine cardiovascular disease management strategies.

Keywords:
ST2biomarkerscardiologygalectin-3

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