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C-KIT Expression in Orbital Cavernous Venous Hemangiomas
Mizhir Atallah1,2, Natalia Edison3, Esther Levi2
1Ophthalmology Department, Emek Medical Center, Afula 18101, Israel.
Biomolecules
|August 27, 2021
Summary
Orbital cavernous venous hemangiomas (OCVH) express the c-KIT receptor, suggesting its role in tumor development. This finding may inform targeted therapies for complex cases.
Area of Science:
- Ophthalmology
- Oncology
- Molecular Biology
Background:
- Orbital cavernous venous hemangiomas (OCVH) are common benign orbital tumors in adults.
- The c-KIT receptor tyrosine kinase is implicated in various tumor pathologies.
Purpose of the Study:
- To investigate the presence and significance of the c-KIT receptor in OCVH.
- To explore potential therapeutic implications of c-KIT expression in OCVH.
Main Methods:
- Retrospective analysis of 16 OCVH cases operated between 2006-2016.
- Immunohistochemistry was used to detect c-KIT receptor expression in tumor specimens.
- Correlation analysis between c-KIT staining intensity and clinicopathological factors.
Main Results:
- c-KIT receptor was expressed by the endothelium in all 16 OCVH specimens.
- Staining intensity varied (strong, moderate, weak) across cases.
- No statistically significant correlation was found between c-KIT staining and tumor size or symptom duration.
Conclusions:
- c-KIT expression suggests a potential role in the pathogenesis of OCVH.
- Targeted therapies like Imatinib Mesylate and Sunitinib may be relevant for complex OCVH, particularly those in the orbital apex.
- Further multicenter studies are warranted to confirm the role of c-KIT in OCVH.
