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Anticoronavirus and Immunomodulatory Phenolic Compounds: Opportunities and Pharmacotherapeutic Perspectives

Naiara Naiana Dejani1, Hatem A Elshabrawy2, Carlos da Silva Maia Bezerra Filho3,4

  • 1Department of Physiology and Pathology, Federal University of Paraíba, João Pessoa 58051-900, Brazil.

Biomolecules
|August 27, 2021
PubMed

Insights

Natural phenolic compounds show promise for treating COVID-19 by fighting the SARS-CoV-2 virus and modulating immune responses. This review explores their dual therapeutic potential for COVID-19 patients.

Area of Science:

  • Virology
  • Immunology
  • Pharmacology

Background:

  • COVID-19, caused by SARS-CoV-2, is a severe respiratory illness linked to high mortality, particularly in individuals with comorbidities.
  • Dysregulated immune responses and systemic inflammation are key factors contributing to severe COVID-19 outcomes.
  • Existing therapeutic strategies focus on antiviral drugs and immune modulation.

Purpose of the Study:

  • To review the dual pharmacological actions of natural phenolic compounds.
  • To assess the applicability of these compounds as a therapeutic strategy for COVID-19.

Main Methods:

  • Literature review of studies on natural phenolic compounds.
  • Analysis of pharmacological properties, including antiviral and immunomodulatory activities.
  • Evaluation of potential applications in managing COVID-19.

Main Results:

  • Natural phenolic compounds possess demonstrated anticoronavirus and immunomodulatory activities.
  • These properties suggest a dual therapeutic action against SARS-CoV-2 infection and associated inflammation.
  • Potential for natural products to complement existing COVID-19 treatments.

Conclusions:

  • Natural phenolic compounds offer a promising avenue for COVID-19 therapeutic development.
  • Their combined antiviral and immunomodulatory effects present a unique strategy for disease management.
  • Further research is warranted to explore clinical applications of these natural products.
Keywords:
COVID-19MERS-CoVMiddle East Respiratory Syndrome VirusSARS-CoVSARS-CoV-2chalconeflavonoidnatural productsplantsviruses

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