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Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review

Susanne N Wijesinghe1, Mark A Lindsay2, Simon W Jones1

  • 1MRC-ARUK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK.

Biomedicines
|August 27, 2021
PubMed

Insights

Oligonucleotide therapies show promise for treating osteoarthritis and rheumatoid arthritis by targeting key cellular pathways involved in joint inflammation and disease progression in preclinical models.

Area of Science:

  • Rheumatology
  • Pharmacology
  • Molecular Biology

Background:

  • Osteoarthritis (OA) and rheumatoid arthritis (RA) are prevalent chronic inflammatory joint diseases with significant unmet clinical needs for improved treatments.
  • The pathology of OA and RA affects multiple joint tissues, including cartilage, synovium, and bone.

Purpose of the Study:

  • To review the potential of oligonucleotide therapies for OA and RA.
  • To examine evidence for oligonucleotide modulation of key cellular pathways in joint inflammation.
  • To assess preclinical in vivo data on oligonucleotide effects on disease progression.

Main Methods:

  • Literature review of oligonucleotide therapy research.
  • Analysis of studies on cellular pathways implicated in OA and RA pathogenesis.
  • Examination of preclinical in vivo models demonstrating therapeutic effects.

Main Results:

  • Oligonucleotides can modulate critical cellular pathways driving inflammatory joint disease.
  • Preclinical data suggest oligonucleotides can impact the progression of OA and RA.

Conclusions:

  • Oligonucleotide-based therapeutics represent a potential new pharmacological strategy for OA and RA.
  • Further research and development are warranted to translate these findings into clinical applications.
Keywords:
antisensebonecartilageoligonucleotidesosteoarthritisrheumatoid arthritissynovitistherapeutics

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