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Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
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MiRNAs and Cancer: Key Link in Diagnosis and Therapy

Yu Shi1,2, Zihao Liu1,2, Qun Lin1,2

  • 1Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510000, China.

Genes
|August 27, 2021
PubMed

Insights

MicroRNAs (miRNAs) are key players in cancer, acting as tumor promoters or suppressors. Advances in miRNA delivery systems are paving the way for new cancer diagnostics and therapeutics.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • MicroRNAs (miRNAs) have emerged as critical regulators in biological processes.
  • Dysregulation of miRNAs is implicated in the development and progression of various cancers.
  • miRNAs can function as either tumor promoters or tumor suppressors, highlighting their complex roles in cancer.

Purpose of the Study:

  • To review recent advances in understanding microRNA biology in the context of cancer.
  • To discuss the potential of miRNAs as diagnostic and therapeutic agents for cancer treatment.
  • To explore the role of miRNA delivery systems in preclinical cancer research.

Main Methods:

  • Literature review of recent studies on miRNAs in cancer.
  • Analysis of the dual role of miRNAs as tumor promoters and suppressors.
  • Examination of current miRNA delivery systems and their preclinical applications.

Main Results:

  • miRNA dysregulation is a common hallmark of cancer.
  • miRNAs show significant potential as biomarkers for cancer diagnosis.
  • Targeted delivery of miRNAs offers promising therapeutic strategies for various cancers.

Conclusions:

  • MicroRNAs represent a significant area of research in oncology.
  • Further development of miRNA-based diagnostics and therapeutics is warranted.
  • Advancements in delivery systems are crucial for realizing the clinical potential of miRNAs in cancer treatment.
Keywords:
cancerdiagnosismicroRNAtherapy

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