Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke
Alexandre Dias1,2, Isabel Silva1,3, Inês Mendes Pinto4
1Department of Neurology, Centro Hospitalar Universitário do Porto (CHUPorto), 4099-001 Porto, Portugal.
Life (Basel, Switzerland)
|August 27, 2021
Summary
Rapid diagnosis of stroke is crucial for effective treatment. This review highlights promising blood biomarkers and point-of-care technologies for faster, accurate stroke diagnosis and differentiation.
Area of Science:
- Neurology
- Biomarkers
- Medical Diagnostics
Background:
- Stroke is a major global cause of death and disability.
- Early and precise diagnosis is critical for effective acute stroke care, as treatment efficacy is time-dependent.
- Current diagnostic methods require optimization for speed and accuracy.
Purpose of the Study:
- To review key blood-protein biomarkers for stroke differential diagnosis.
- To identify biomarkers capable of distinguishing between ischemic and hemorrhagic stroke.
- To provide an overview of emerging point-of-care (POC) technologies for rapid stroke diagnostics.
Main Methods:
- Literature review of well-documented blood-protein biomarkers for stroke.
- Analysis of recent advancements in point-of-care biosensor technology.
- Discussion on integrating biomarker data with clinical and imaging parameters.
Main Results:
- Several blood-protein biomarkers show significant potential for clinical translation in stroke diagnosis.
- Point-of-care technologies are advancing for rapid, accessible stroke detection.
- Multi-dimensional algorithms integrating biomarkers, clinical data, and neuroimaging are emerging.
Conclusions:
- Blood biomarkers and POC technologies offer a promising avenue for improving acute stroke diagnosis.
- Personalized stroke care will benefit from integrating fluid-based biomarker profiling with other clinical data.
- Further development and validation are needed for widespread clinical adoption.
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Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
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01:17Hemorrhagic Stroke l: Introduction
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