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Related Experiment Video

Updated: Oct 22, 2025

Two-photon Calcium Imaging in Neuronal Dendrites in Brain Slices
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Two-photon Calcium Imaging in Neuronal Dendrites in Brain Slices

Published on: March 15, 2018

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Lighting Up Ca2+ Dynamics in Animal Models.

Nelly Redolfi1, Paloma García-Casas1, Chiara Fornetto1

  • 1Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.

Cells
|August 27, 2021
PubMed
Summary

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Calcium (Ca2+) signaling is vital for brain function, but disruptions are linked to neurodegeneration. Calcium imaging in animal models offers powerful insights into these brain diseases.

Area of Science:

  • Neuroscience
  • Cellular Physiology
  • Neurodegenerative Disease Research

Background:

  • Calcium (Ca2+) signaling regulates essential neuronal functions like synaptic transmission, plasticity, and survival.
  • Impaired Ca2+ homeostasis is implicated in aging and the progression of neurodegenerative diseases.
  • Understanding Ca2+ dysregulation is critical for addressing brain dysfunction.

Purpose of the Study:

  • To review the utility of animal models for Ca2+ imaging in neuroscience.
  • To highlight how Ca2+ imaging aids in studying neurodegenerative disease pathogenesis.
  • To underscore the role of Ca2+ sensors and imaging technology advancements.

Main Methods:

  • Exploration of commonly used animal models for Ca2+ imaging.
Keywords:
GECIanimal modelscalcium imagingcalcium indicatorsnervous system

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Last Updated: Oct 22, 2025

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  • Analysis of Ca2+ imaging applications in brain research.
  • Review of advancements in Ca2+ sensors and imaging instrumentation.

    • Main Results:

    • Ca2+ imaging is a powerful tool for investigating brain physiology.
    • Animal models provide valuable platforms for Ca2+ dynamics studies.
    • Technological improvements enhance the scope of Ca2+ imaging in neuroscience.

    Conclusions:

    • Ca2+ imaging in animal models is instrumental for understanding neurodegenerative disease mechanisms.
    • Continued advancements in Ca2+ sensors and imaging will further illuminate brain function and dysfunction.
    • This approach is key to unraveling the complexities of Ca2+ signaling in health and disease.