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Updated: Oct 22, 2025
Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
Published on: October 27, 2023
The Role of microRNAs in Pulp Inflammation
José Luis Muñoz-Carrillo1, Silverio Jafet Vázquez-Alcaraz2, Jazmín Monserrat Vargas-Barbosa1
1Laboratory of Basic Sciences, School of Odontology, Universidad Cuauhtémoc Aguascalientes, Aguascalientes 20196, Mexico.
Abstract:
The dental pulp can be affected by thermal, physical, chemical, and bacterial phenomena that stimulate the inflammatory response. The pulp tissue produces an immunological, cellular, and vascular reaction in an attempt to defend itself and resolve the affected tissue. The expression of different microRNAs during pulp inflammation has been previously documented. MicroRNAs (miRNAs) are endogenous small molecules involved in the transcription of genes that regulate the immune system and the inflammatory response. They are present in cellular and physiological functions, as well as in the pathogenesis of human diseases, becoming potential biomarkers for diagnosis, prognosis, monitoring, and safety. Previous studies have evidenced the different roles played by miRNAs in proinflammatory, anti-inflammatory, and immunological phenomena in the dental pulp, highlighting specific key functions of pulp pathology. This systematized review aims to provide an understanding of the role of the different microRNAs detected in the pulp and their effects on the expression of the different target genes that are involved during pulp inflammation.
Insights
MicroRNAs (miRNAs) play crucial roles in dental pulp inflammation by regulating immune responses and gene expression. This review explores their function in pulp pathology and potential as biomarkers.
Area of Science:
- Dentistry
- Molecular Biology
- Immunology
Background:
- Dental pulp inflammation is a complex response to various stimuli.
- MicroRNAs (miRNAs) are key regulators of gene expression involved in cellular and immunological functions.
- miRNAs have been implicated in the pathogenesis of various diseases, including dental pulp conditions.
Purpose of the Study:
- To systematically review the role of microRNAs (miRNAs) in dental pulp inflammation.
- To understand the effects of miRNAs on target gene expression during pulp inflammation.
- To highlight the potential of miRNAs as biomarkers in pulp pathology.
Main Methods:
- Systematic review of existing literature.
- Analysis of studies documenting miRNA expression in inflamed dental pulp.
- Evaluation of the functional roles of identified miRNAs in inflammatory pathways.
Main Results:
- MicroRNAs (miRNAs) exhibit diverse roles in modulating proinflammatory and anti-inflammatory responses within the dental pulp.
- Specific miRNAs are differentially expressed during pulp inflammation, affecting key signaling pathways.
- Evidence suggests miRNAs are involved in the immunological and cellular defense mechanisms of the dental pulp.
Conclusions:
- MicroRNAs (miRNAs) are significant regulators of dental pulp inflammation and immune responses.
- Understanding miRNA functions provides insights into pulp pathology.
- miRNAs hold promise as diagnostic and prognostic biomarkers for dental pulp diseases.
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