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Updated: Oct 22, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
Walk Your Talk: Real-World Adherence to Guidelines on the Use of MRI in Multiple Sclerosis
Mario Tortora1, Mario Tranfa1, Anna Chiara D'Elia1
1Department of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.
Abstract:
(1) Although guidelines about the use of MRI sequences for Multiple Sclerosis (MS) diagnosis and follow-up are available, variability in acquisition protocols is not uncommon in everyday clinical practice. The aim of this study was to evaluate the real-world application of MS imaging guidelines in different settings to clarify the level of adherence to these guidelines. (2) Via an on-line anonymous survey, neuroradiologists (NR) were asked about MRI protocols and parameters routinely acquired when MS patients are evaluated in their center, both at diagnosis and follow-up. Furthermore, data about report content and personal opinions about emerging neuroimaging markers were also retrieved. (3) A total of 46 participants were included, mostly working in a hospital or university hospital (80.4%) and with more than 10 years of experience (47.9%). We found a relatively good adherence to the suggested MRI protocols regarding the use of T2-weighted sequences, although almost 10% of the participants routinely acquired 2D sequences with a slice thickness superior to 3 mm. On the other hand, a wider degree of heterogeneity was found regarding gadolinium administration, almost routinely performed at follow-up examination (87.0% of cases) in contrast with the current guidelines, as well as a low use of a standardized reporting system (17.4% of cases). (4) Although the MS community is getting closer to a standardization of MRI protocols, there is still a relatively wide heterogeneity among NR, with particular reference to contrast administration, which must be overcome to guarantee an adequate quality of patients' care in MS.
Insights
MRI imaging protocols for Multiple Sclerosis (MS) show good adherence to guidelines for sequence selection but significant variability in contrast administration and reporting. Standardization is needed for consistent patient care.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Guidelines exist for Multiple Sclerosis (MS) MRI diagnosis and follow-up.
- Clinical practice often shows variability in MRI acquisition protocols.
- Real-world adherence to MS imaging guidelines requires evaluation.
Purpose of the Study:
- To assess the adherence to MS imaging guidelines in clinical practice.
- To identify variability in MRI protocols used for MS diagnosis and follow-up.
- To explore neuroradiologists' opinions on emerging neuroimaging markers.
Main Methods:
- An anonymous online survey was distributed to neuroradiologists.
- The survey queried MRI protocols, parameters, and reporting practices for MS patients.
- Data on gadolinium administration and use of standardized reporting were collected.
Main Results:
- Good adherence to T2-weighted sequence protocols was observed.
- Nearly 10% of participants used slice thickness >3 mm for 2D sequences.
- Significant heterogeneity exists in gadolinium administration (87% routinely used at follow-up) and standardized reporting (17.4%).
Conclusions:
- While MS imaging protocol standardization is progressing, heterogeneity persists among neuroradiologists.
- Variability in contrast administration and reporting requires attention.
- Standardization is crucial for ensuring high-quality patient care in MS management.
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