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Hypercoagulable State in COPD-A Comprehensive Literature Review.
Christos Kyriakopoulos1, Athena Gogali1, Konstantinos Kostikas1
1Respiratory Medicine Department, Faculty of Medicine, University of Ioannina, 45500 Ioannina, Greece.
Chronic Obstructive Pulmonary Disease (COPD) involves inflammation and affects multiple body systems. This review details how COPD, both stable and during exacerbations, alters coagulation factors and increases prothrombotic risks, linking it to cardiovascular events.
Area of Science:
- Pulmonary Medicine
- Hematology
- Cardiovascular Medicine
Background:
- Chronic Obstructive Pulmonary Disease (COPD) is a systemic inflammatory condition.
- COPD is linked to increased risks of venous thromboembolism and cardiovascular events.
- Understanding coagulation changes in COPD is crucial for managing these risks.
Purpose of the Study:
- To review literature on coagulation factor alterations in COPD.
- To explore prothrombotic changes in stable COPD and during exacerbations.
- To provide an in-depth overview of the relationship between COPD and coagulation.
Main Methods:
- Comprehensive literature review.
- Analysis of studies on stable COPD patients.
- Examination of studies on COPD exacerbations.
Main Results:
- COPD is associated with significant alterations in coagulation factors.
- Prothrombotic changes are evident in both stable COPD and during exacerbations.
- These changes contribute to the increased risk of thrombotic events.
Conclusions:
- COPD patients exhibit a prothrombotic state.
- Coagulation alterations are a key feature of COPD pathophysiology.
- Further research is needed to explore therapeutic interventions targeting coagulation in COPD.
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