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Serum Sclerostin Is Associated with Peripheral and Central Systolic Blood Pressure in Pediatric Patients with Primary

Piotr Skrzypczyk1, Anna Ofiara1, Michał Szyszka2

  • 1Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland.

Journal of Clinical Medicine
|August 27, 2021
PubMed

Insights

Serum sclerostin levels did not differ between pediatric hypertension patients and controls, but were associated with blood pressure and height in children. This suggests a link between sclerostin and blood pressure regulation in pediatric hypertension.

Area of Science:

  • Cardiovascular Research
  • Pediatric Endocrinology
  • Biochemistry

Background:

  • The Wnt/beta-catenin pathway and its inhibitor, sclerostin, are implicated in arterial damage and cardiovascular outcomes.
  • Understanding sclerostin's role in pediatric primary hypertension (PH) is crucial for assessing cardiovascular risk.

Purpose of the Study:

  • To evaluate serum sclerostin concentration in children and adolescents with PH.
  • To investigate the relationship between serum sclerostin and blood pressure, arterial damage, and calcium-phosphate metabolism in this population.

Main Methods:

  • Serum sclerostin levels were measured in 60 pediatric PH patients and 20 healthy controls.
  • Assessed calcium-phosphate metabolism, peripheral and central blood pressure (office and 24-h ambulatory), and arterial damage parameters.
  • Utilized multivariate analysis to identify determinants of serum sclerostin.

Main Results:

  • No significant difference in serum sclerostin was found between PH patients and controls.
  • Sclerostin correlated positively with height Z-score, phosphate, and alkaline phosphatase.
  • Sclerostin correlated negatively with age, peripheral systolic/mean blood pressure, and central systolic/mean blood pressure.
  • Multivariate analysis identified height Z-score and systolic blood pressure Z-score as significant determinants of serum sclerostin.

Conclusions:

  • Serum sclerostin levels are associated with blood pressure and height in the pediatric population.
  • These findings suggest a potential role for sclerostin in blood pressure regulation within pediatric hypertension.
  • Further research is warranted to elucidate the precise mechanisms involved.

Keywords:
adolescentsarterial damageblood pressurechildrenprimary hypertensionsclerostin

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