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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
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Diagnosis of Cardiac Surgery-Associated Acute Kidney Injury

Christina Massoth1, Alexander Zarbock1

  • 1Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, A1, 48149 Münster, Germany.

Journal of Clinical Medicine
|August 27, 2021
PubMed

Insights

Acute kidney injury after cardiac surgery (CSA-AKI) requires better diagnostic criteria beyond current classifications. This review examines limitations and highlights the importance of biomarkers for timely management.

Area of Science:

  • Nephrology
  • Cardiology
  • Critical Care Medicine

Background:

  • Acute kidney injury following cardiac surgery (CSA-AKI) presents unique damage and recovery patterns crucial for patient outcomes.
  • Current diagnostic frameworks, like the Kidney Disease: Improving Global Outcomes (KDIGO) classification, offer incomplete assessments for CSA-AKI.
  • Understanding CSA-AKI as a time-sensitive condition necessitates improved diagnostic approaches.

Purpose of the Study:

  • To critically evaluate the strengths and limitations of existing diagnostic criteria for CSA-AKI.
  • To provide a comprehensive overview of current and emerging biomarkers for CSA-AKI detection.
  • To emphasize the need for enhanced diagnostic criteria and clinical integration of biomarkers.

Main Methods:

  • Literature review of recent studies on CSA-AKI diagnosis and biomarkers.
  • Analysis of the KDIGO classification's applicability and shortcomings in the context of cardiac surgery.
  • Synthesis of information on various biomarkers associated with CSA-AKI.

Main Results:

  • The KDIGO classification is insufficient for a complete diagnosis of CSA-AKI.
  • Several biomarkers show promise for early and accurate detection of CSA-AKI.
  • There is a growing demand for improved diagnostic tools and biomarker translation.

Conclusions:

  • Existing diagnostic criteria for CSA-AKI are limited and require enhancement.
  • Biomarkers are essential for the timely diagnosis and management of CSA-AKI.
  • Further research and clinical implementation of biomarkers are needed to improve patient care after cardiac surgery.

Keywords:
acute kidney injurybiomarkerscardiac surgerycardiopulmonary bypass

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