Related Experiment Video
Updated: Oct 22, 2025
06:22
Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
Published on: November 29, 2024
901
Diabetes Mellitus and Heart Failure
Filippos Triposkiadis1, Andrew Xanthopoulos1, Alexandra Bargiota2
1Department of Cardiology, University General Hospital of Larissa, 411 10 Larissa, Greece.
Journal of Clinical Medicine
|August 27, 2021
Summary
Diabetes mellitus (DM) significantly increases heart failure (HF) risk due to hyperglycemia and metabolic issues. New heart failure treatments may also prevent diabetes development, suggesting a bidirectional relationship.
Area of Science:
- Cardiology
- Endocrinology
- Metabolic Diseases
Background:
- Diabetes mellitus (DM) is a major risk factor for new-onset heart failure (HF), and vice versa.
- The complex pathogenesis involves hyperglycemia, diabetic cardiomyopathy, and comorbidities like hypertension and coronary artery disease.
- HF in type 1 DM involves immune dysregulation, while type 2 DM is often linked to overweight/obesity.
Purpose of the Study:
- To explore the intricate relationship between diabetes mellitus and heart failure.
- To discuss the pathogenesis of heart failure in diabetic patients and vice versa.
- To evaluate the impact of novel heart failure medications on cardiogenic diabetes.
Main Methods:
- Review of existing literature on the pathophysiology of DM and HF.
- Analysis of the mechanisms underlying diabetic cardiomyopathy and cardiogenic diabetes.
- Discussion of the cardiovascular effects of hyperglycemia and metabolic abnormalities.
Main Results:
- Diabetes significantly elevates the risk of developing heart failure through various mechanisms.
- Heart failure can lead to new-onset type 2 diabetes (cardiogenic DM), worsening cardiac function.
- Newer HF medications like sacubitril/valsartan and SGLT-2 inhibitors show promise in preventing cardiogenic diabetes.
Conclusions:
- Rigorous management of cardiovascular risk factors and selective antidiabetic agents can prevent HF in DM.
- Cardiogenic DM exacerbates HF outcomes, highlighting the need for integrated management.
- The potential of mitigating cardiogenic DM as a therapeutic target in HF warrants further investigation.
Related Concept Videos
01:27Heart Failure I: Introduction
159
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
159
01:17Pathophysiology of Heart Failure
2.0K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.0K
01:29Heart Failure II: Pathophysiology
108
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
108
01:22Heart Failure Drugs: Diuretics
544
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
544
01:30Heart Failure IV: Classification and Diagnostic Evaluation
74
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
74
01:30Heart Failure VII: Nursing Interventions
194
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
194