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Production of Germ-Free Fast-Growing Broilers from a Commercial Line for Microbiota Studies

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Infection Heterogeneity and Microbiota Differences in Chicks Infected by Salmonella enteritidis.

Shu Wu^1,2, Guanglei Cong², Qianyun Zhang²

¹College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.

|August 27, 2021

Summary

Chicks exhibit varied responses to Salmonella enteritidis infection. Resistant chicks show improved intestinal barrier function and a distinct cecal microbiota, including higher Desulfovibrio piger levels, aiding resistance.

Keywords:

Desulfovibrio_piger Salmonella enteritidis cecal microbiome heterogeneity intestinal barrier

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Area of Science:

Animal Science
Microbiology
Immunology

Background:

Salmonella enteritidis (S. enteritidis) infection poses a significant challenge in poultry production.
Understanding host responses and microbial interactions is crucial for managing infections.

Purpose of the Study:

To investigate the heterogeneity of S. enteritidis infection in chicks.
To compare the cecal microbiota composition between susceptible and resistant chicks.

Main Methods:

Arbor Acres chicks were challenged with S. enteritidis.
Chicks were categorized into susceptible (Group S) and resistant (Group R) based on Salmonella tissue loads.
Cecal microbiota and intestinal gene expression were analyzed.

Main Results:

Group S chicks displayed higher liver index and lesions compared to Group R.
Group R exhibited enhanced expression of intestinal barrier genes (occludin, MUC2, IL10) and reduced inflammatory genes (iNOS, IL6).
Distinct cecal microbial communities were observed, with pathogenic bacteria enriched in Group S and Desulfovibrio piger in Group R.

Conclusions:

Chicks demonstrate heterogeneous responses to S. enteritidis infection.
Enhanced intestinal barrier function and a specific cecal microbiota profile, particularly the abundance of Desulfovibrio piger, are associated with resistance to S. enteritidis.