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Related Experiment Video

Updated: Oct 22, 2025

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes

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Published on: February 13, 2019

Solvatomorphism of Moxidectin.

Toni Grell¹, Mauro Barbero², Franco Pattarino²

¹Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, I-20133 Milano, Italy.

Molecules (Basel, Switzerland)

|August 27, 2021

Summary

Researchers explored the solvatomorphism of moxidectin, discovering a new nitromethane solvatomorph. Crystal structures and thermal properties of ethanol and 2-propanol solvatomorphs were analyzed, offering crystallochemical insights into this anthelmintic drug.

Keywords:

X-ray diffraction moxidectin solvatomorphism variable-temperature PXRD

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Area of Science:

Pharmaceutical Chemistry
Solid-State Chemistry
Crystallography

Background:

Moxidectin is a vital anthelmintic drug.
Understanding its solid-state forms (solvatomorphs) is crucial for drug formulation and stability.
Previous studies have not fully detailed its solvatomorphism.

Purpose of the Study:

To investigate the solvatomorphism of moxidectin.
To report novel solvatomorphs and elucidate their crystal structures.
To characterize the thermal behavior of moxidectin solvatomorphs.

Main Methods:

Solvent screening to identify new solvatomorphs.
Single-crystal and powder X-ray diffraction (PXRD) for structural analysis.
Variable-temperature powder X-ray diffraction (VT-PXRD) for thermal characterization.

Main Results:

A new moxidectin solvatomorph with nitromethane was successfully synthesized and characterized.
The crystal structures of moxidectin solvatomorphs with ethanol and 2-propanol were determined for the first time.
VT-PXRD analysis provided insights into the thermal transitions and stability of these solvatomorphs.

Conclusions:

The study expands the known solvatomorphic landscape of moxidectin.
Detailed structural and thermal data enhance the understanding of moxidectin's crystallochemistry.
Findings contribute to the rational design of moxidectin formulations with improved properties.