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Related Experiment Videos

Resistance in the sheep's lymphatic system.

C Pippard1, I C Roddie

  • 1Department of Physiology, Queen's University of Belfast, Northern Ireland.

Lymphology
|December 1, 1987
PubMed
Summary

The peripheral lymphatic system in sheep presents significant resistance to lymph flow. High intralymphatic pressure is essential for effective lymph return, particularly at elevated flow rates.

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Area of Science:

  • Physiology
  • Lymphatic System Dynamics

Background:

  • The lymphatic system is crucial for fluid homeostasis and immune function.
  • Understanding peripheral lymphatic resistance is vital for managing lymphedema and related conditions.

Purpose of the Study:

  • To quantify the resistance of the peripheral lymphatic system in sheep.
  • To determine the intralymphatic pressures required to achieve physiological lymph flow rates.

Main Methods:

  • Saline infusion into afferent lymphatics of anesthetized sheep's metacarpal region.
  • Measurement of inflow pressure across a range of flow rates (10-2000 µL/min).
  • Assessment of isoprenaline's effect on lymphatic resistance and contractility.

Main Results:

  • Physiological flow rates generated mean pressures of approximately 30 mmHg.
  • Lymphatic resistance was high at low flow rates (<15 µL/min) but decreased significantly at higher flows (>500 µL/min).
  • Isoprenaline reduced spontaneous contractions and lowered resistance at lower flow rates.

Conclusions:

  • The sheep peripheral lymphatic system exhibits substantial resistance to lymph flow.
  • Significant intralymphatic pressure is necessary for peripheral lymph return, especially under high flow conditions.

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