Plant Adaptogens-History and Future Perspectives
Velislava Todorova1, Kalin Ivanov1, Cédric Delattre2,3
1Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria.
Plant adaptogens enhance bodily stability against physical stress without increasing oxygen needs. Research indicates their potential benefits for chronic fatigue, cognitive function, and immune support, with future therapeutic applications.
Area of Science:
- Pharmacology and Herbal Medicine
- Natural Product Chemistry
Background:
- Adaptogens, including plant extracts and synthetic compounds, enhance physiological stability under stress.
- Specific plant adaptogens include extracts from Panax ginseng, Eleutherococcus senticosus, Rhaponticum carthamoides, Rhodiola rosea, and Schisandra chinensis.
- Historically, natural adaptogens have been used for recovery from illness and weakness.
Observation:
- Plant adaptogens were first utilized in professional sports approximately 50 years ago to improve stress resistance and physical endurance.
- Current use of plant adaptogens is widespread, yet human clinical trials remain limited.
- Meta-analysis data suggests potential benefits of plant adaptogens in managing chronic fatigue, cognitive impairment, and immune function.
Findings:
- Plant adaptogens improve the body's resistance to physical loads and stress.
- Evidence suggests efficacy in treating chronic fatigue and cognitive deficits.
- Potential for immune system enhancement has been observed.
Implications:
- Plant adaptogens hold promise for future therapeutic applications.
- There is significant potential for developing registered medicinal products containing plant adaptogens.
- Further clinical research is warranted to fully establish efficacy and safety profiles.
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