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Protective Effects of Flavonoids Against Mitochondriopathies and Associated Pathologies: Focus on the Predictive

Lenka Koklesova1, Alena Liskova1, Marek Samec1

  • 1Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.

International Journal of Molecular Sciences
|August 27, 2021
PubMed

Insights

Flavonoids show promise in protecting against mitochondrial damage and related diseases. This review explores their therapeutic potential for predictive, preventive, and personalized medicine (3PM) strategies.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Pharmacology

Background:

  • Mitochondrial damage creates a cycle of dysfunction, impacting multiple organs and leading to diseases like cancer, cardiovascular issues, and neurodegeneration.
  • The specific pathologies resulting from mitochondrial impairments (mitochondriopathies) vary significantly between individuals.
  • Predictive, preventive, and personalized medicine (3PM) is essential for effective, individualized patient care.

Purpose of the Study:

  • To review preclinical and clinical data on the efficacy of flavonoids in protecting against mitochondriopathies.
  • To evaluate flavonoids as a therapeutic strategy within the framework of 3PM.
  • To explore the role of flavonoids in mitigating mitochondrial damage and associated pathologies.

Main Methods:

  • Systematic review of existing preclinical and clinical research.
  • Analysis of studies investigating flavonoid antioxidant and scavenging activities.
  • Evaluation of data on flavonoid efficacy in preventing or treating mitochondriopathies and related diseases.

Main Results:

  • Flavonoids possess significant antioxidant and free radical scavenging properties.
  • Evidence suggests flavonoids can protect against mitochondrial damage.
  • Research indicates potential therapeutic utility of flavonoids in managing mitochondriopathies and associated conditions.

Conclusions:

  • Flavonoids are promising agents for combating mitochondrial damage and related pathologies.
  • Their application aligns with the principles of predictive, preventive, and personalized medicine (3PM).
  • Further research into flavonoids could lead to novel therapeutic strategies for diverse diseases.
Keywords:
anti-oxidant activitycancercardiovascular diseasedysfunctionflavonoidsgenoprotectioninjurymitochondrial functionmitochondrial impairmentmitochondriopathynatural substancesneurodegenerationpatient stratificationphytochemicalspredictive preventive personalized medicine (PPPM/3PM)stresstumorigenesis

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