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Related Concept Videos

Protein and Protein Structure02:15

Protein and Protein Structure

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
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Conservation of Protein Domains Over Different Proteins02:26

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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Conserved Binding Sites01:49

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Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
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Protein Structure Analysis and Prediction with Statistical Scoring Functions.

Peter Lackner1, Markus Wiederstein1

  • 1Department of Biosciences, University of Salzburg, 5020 Salzburg, Austria.

International Journal of Molecular Sciences
|August 27, 2021
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Summary
This summary is machine-generated.

The Protein Data Bank (PDB) is a vital resource, offering over 150,000 structures of biological macromolecules. This extensive database supports research in structural biology and drug discovery.

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Area of Science:

  • Structural Biology
  • Biochemistry
  • Molecular Biology

Background:

  • The Protein Data Bank (PDB) archives experimental data for biological macromolecular structures.
  • It serves as a central repository for researchers worldwide, facilitating access to structural information.

Discussion:

  • The PDB database contains over 150,000 entries, representing a vast collection of structural data.
  • This data is crucial for understanding biological processes at a molecular level.

Key Insights:

  • The sheer volume of PDB entries underscores its importance in advancing structural biology.
  • Accessibility to this data drives innovation in fields like medicine and biotechnology.

Outlook:

  • Future growth of the PDB will continue to expand our knowledge of molecular structures.
  • Continued curation and accessibility of PDB data will be essential for future scientific endeavors.