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Published on: September 20, 2017
Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers
Guangyan Zhang1,2, Hui Yi1, Chenhui Bao1
1School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, China.
Abstract:
Poly(aspartamide) derivatives, one kind of amino acid-based polymers with excellent biocompatibility and biodegradability, meet the key requirements for application in various areas of biomedicine. Poly(aspartamide) derivatives with stimuli-responsiveness can usually respond to external stimuli to change their chemical or physical properties. Using external stimuli such as temperature and pH as switches, these smart poly(aspartamide) derivatives can be used for convenient drug loading and controlled release. Here, we review the synthesis strategies for preparing these stimuli-responsive poly(aspartamide) derivatives and the latest developments in their applications as drug carriers.
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