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Related Concept Videos

Structure of Lipids03:38

Structure of Lipids

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Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
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Lipid-derived Compounds in the Human Body01:31

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Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
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Lipids as Anchors01:32

Lipids as Anchors

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In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
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Overview of Fatty Acid Metabolism01:28

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Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
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Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Overview01:20

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The Fischer esterification reaction was developed by the German chemist Emil FischerĀ in 1895. It is a condensation reaction between carboxylic acids and alcohols in an acidic medium to give esters and water.
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What are Lipids?01:38

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Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death
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Angioedema and Fatty Acids.

Akane Wada1, Yu Sawada1, Hitomi Sugino1

  • 1Department of Dermatology, Faculty of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanisi-Ku, Kitakyushu, Fukuoka 807-8555, Japan.

International Journal of Molecular Sciences
|August 27, 2021
PubMed
Summary

Fatty acids may play a role in angioedema, a serious condition. Research suggests these molecules influence vascular permeability and vasodilation, potentially contributing to difficult-to-treat cases.

Keywords:
angioedemafatty acidshereditary angioedema

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Area of Science:

  • Biochemistry
  • Physiology
  • Pathology

Background:

  • Angioedema is a critical condition linked to bradykinin and histamine pathways.
  • Current treatments are sometimes ineffective, particularly for histamine-mediated angioedema.
  • This suggests other mediators may be involved in angioedema development.

Purpose of the Study:

  • To review the role of fatty acids in vascular permeability and vasodilation.
  • To explore the potential pathogenetic role of fatty acids in angioedema.
  • To summarize fatty acid functions and receptor signaling in blood vessels.

Main Methods:

  • Literature review of studies on fatty acids and vascular responses.
  • Analysis of fatty acid functions and receptor signaling pathways.
  • Focus on the connection between fatty acids and angioedema pathogenesis.

Main Results:

  • Fatty acids are implicated in vascular permeability and vasodilation.
  • These actions occur alongside bradykinin and histamine-mediated reactions.
  • Specific fatty acid functions and receptor signaling in blood vessels are detailed.

Conclusions:

  • Fatty acids represent potential mediators in angioedema.
  • Understanding their role may lead to new therapeutic strategies for intractable angioedema.
  • Further research into fatty acid pathways is warranted.