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Redox Signaling and Sarcopenia: Searching for the Primary Suspect

Nicholas A Foreman1, Anton S Hesse1, Li Li Ji1

  • 1Laboratory of Physiological Hygiene and Exercise Science, School of Kinesiology, College of Education and Human Development, University of Minnesota, 1900 University Ave, Minneapolis, MN 55455, USA.

International Journal of Molecular Sciences
|August 27, 2021
PubMed

Insights

Sarcopenia, an age-related loss of muscle, is linked to reactive oxygen species (ROS). Understanding redox signaling and mitochondrial dysfunction is key to combating this aging health hazard.

Area of Science:

  • Gerontology
  • Muscle Physiology
  • Molecular Biology

Background:

  • Sarcopenia is an age-related decline in muscle mass and function.
  • Reactive oxygen species (ROS) are implicated in sarcopenia's development.
  • Multiple etiological mechanisms contribute to sarcopenia.

Purpose of the Study:

  • To review signaling pathways controlling muscle integrity.
  • To explore the role of redox signaling in sarcopenia.
  • To highlight mitochondrial homeostasis in aging muscle.

Main Methods:

  • Literature review of signaling pathways in sarcopenia.
  • Analysis of redox signaling dysregulation.
  • Examination of mitochondrial function in aging.

Main Results:

  • Age-associated redox signaling dysregulation is a key factor in sarcopenia.
  • Mitochondrial homeostasis disruption contributes significantly to sarcopenia.
  • No single pathway fully explains sarcopenia, but interconnected mechanisms are evident.

Conclusions:

  • Redox signaling and mitochondrial dysfunction are critical in sarcopenia.
  • Further research is needed to fully understand sarcopenia's mechanisms.
  • Targeting these pathways may offer therapeutic strategies for age-related muscle loss.
Keywords:
agingmitochondriaperoxiredoxinredox signalingsarcopeniaskeletal muscle

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