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Analysis of the Potential Genetic Links between Psoriasis and Cardiovascular Risk Factors

Dorota Purzycka-Bohdan1, Anna Kisielnicka1, Michał Bohdan2

  • 1Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-214 Gdansk, Poland.

International Journal of Molecular Sciences
|August 27, 2021
PubMed

Insights

Psoriasis patients have more cardiovascular risks like hypertension and diabetes due to shared genetic factors. Understanding these links can improve psoriasis and cardiovascular disease management.

Area of Science:

  • Dermatology and Cardiovascular Medicine

Background:

  • Psoriasis is frequently associated with cardiovascular risk factors.
  • Psoriatic patients exhibit higher rates of hypertension, type 2 diabetes, dyslipidemia, obesity, metabolic syndrome, and cardiovascular disease compared to the general population.

Purpose of the Study:

  • To review current knowledge on potential genetic links between psoriasis and cardiovascular risk factors.
  • To explore the shared genetic pathways contributing to these comorbidities.

Main Methods:

  • Literature review of studies investigating genetic associations between psoriasis and cardiovascular risk factors.
  • Analysis of data on pleiotropic genetic interactions in systemic inflammatory disorders.

Main Results:

  • Evidence suggests shared genetic pathways contribute to psoriasis and associated cardiovascular risks.
  • Genetic factors play a role in the pleiotropic interactions observed in psoriatic disease.

Conclusions:

  • Understanding the genetic basis of comorbidities in psoriasis is crucial.
  • Identifying genetic links can inform future therapeutic strategies for managing psoriasis and cardiovascular risk.

Keywords:
cardiovascular riskcomorbiditiesgenetic backgroundpsoriasis

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