Alteration of trabecular aqueous flow after cataract extraction

Two human eyes that had undergone intracapsular cataract extraction were perfused with cationized ferritin. In both eyes segmental areas of trabecular meshwork collapse were demonstrated superiorly, adjacent to the cataract incision. Electron-microscopic study of these regions disclosed no labeling of the trabecular beams and trabecular spaces, suggesting impermeability to aqueous flow. In other regions, a diffuse labeling with cationized ferritin was demonstrated throughout the trabecular spaces, indicating aqueous flowthrough. Use of corneoscleral sutures may cause trabecular collapse and impermeability. When the collapse is extensive, subsequent increase in intraocular pressure may follow.