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Updated: Oct 22, 2025

Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Platelet dysfunction in patients with traumatic intracranial hemorrhage: Do desmopressin and platelet therapy help or
Nina E Glass1, Julia Riccardi2, Helen Horng3
1Department of Surgery, Division of Trauma and Surgical Critical Care, Rutgers New Jersey Medical School, 185 S Orange Ave, Newark, New Jersey, 07101, USA.
Background:
Pre-injury anti-platelet use has been associated with increased risk of progression of traumatic intracranial hemorrhage (TICH) and worse outcomes. VerifyNow® assays assess platelet inhibition due to aspirin/clopidogrel. This study assesses the outcomes of patients with TICH and platelet dysfunction treated with desmopressin and/or platelets.
Methods:
We performed a retrospective chart review of patients with mild TICH at a level 1 trauma center 1/1/2013-6/1/2016. Patients with documented platelet dysfunction who received desmopressin and/or platelets were compared to those who were untreated. Primary outcomes were progression of TICH and neurologic outcomes at discharge.
Results:
Of 565 patients with a mild TICH, 200 patients had evidence of platelet dysfunction (a positive VerifyNow® assay). Patients had similar baseline demographics, injury characteristics, and rate of TICH progression; but patients who received desmopressin and/or platelets had worse Glasgow Outcomes Score at discharge.
Conclusion:
Treatment of patients with mild TICH and platelet dysfunction with desmopressin and/or platelets did not affect TICH progression but correlated with worse neurologic status at discharge.
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