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[Danaparoid Sodium Controlled Chronic Disseminated Intravascular Coagulation Associated with Chronic Aortic

Okihiko Akashi1, Sadahiro Kanemura, Kensuke Kobayashi

  • 1Department of Cardiovascular Surgery, Ikegami General Hospital, Tokyo, Japan.

Kyobu Geka. the Japanese Journal of Thoracic Surgery
|August 27, 2021
PubMed

Insights

Management of chronic disseminated intravascular coagulation (DIC) from aortic dissection is challenging. This case study shows danaparoid sodium effectively stabilized coagulative parameters and reduced bleeding in a patient with aortic dissection and a patent false lumen.

Area of Science:

  • Cardiology
  • Hematology
  • Vascular Surgery

Background:

  • Chronic disseminated intravascular coagulation (DIC) associated with aortic dissection lacks established management protocols.
  • Aortic dissection, particularly with a patent false lumen, presents complex challenges in coagulation management.

Observation:

  • A patient with chronic DIC secondary to aortic dissection experienced an acute exacerbation.
  • The patient had a patent false lumen, complicating the DIC management.

Findings:

  • Treatment with danaparoid sodium (2,000 U/day) successfully stabilized both coagulative and fibrinolytic parameters.
  • Danaparoid sodium effectively relieved bleeding tendencies without any observed side effects during long-term administration.

Implications:

  • This case suggests danaparoid sodium may be a viable therapeutic option for managing acute exacerbations of chronic DIC in aortic dissection patients.
  • Further research is warranted to explore the efficacy and safety of danaparoid sodium in similar complex cardiovascular and hematological conditions.

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