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Updated: Oct 22, 2025

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A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm

Luca Mariani1, Xiaogang Guo1, Niels Alvaro Menezes1

  • 1Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark.

Nature Communications
|August 27, 2021
PubMed
Summary

Cells use a BRACHYURY-TALE/HOX code to control gene expression during development. This mechanism ensures proper lineage specification by regulating chromatin accessibility and WNT signaling in neuromesodermal progenitors.

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