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Association between polygenic propensity for psychiatric disorders and nutrient intake.

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Genetic predisposition to psychiatric disorders is linked to dietary habits. Higher genetic risk for ADHD, bipolar disorder, and schizophrenia correlated with specific nutrient intake patterns, influencing eating behaviors.

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Area of Science:

  • Psychiatric Genetics
  • Nutritional Psychiatry
  • Behavioral Science

Background:

  • Observed associations exist between psychiatric disorders and nutrient intake.
  • Genetic underpinnings of these associations remain underexplored.
  • Understanding genetic links can inform targeted interventions.

Purpose of the Study:

  • To investigate the association between polygenic scores for psychiatric disorders and nutrient intake.
  • To identify specific psychiatric disorders with significant genetic links to dietary patterns.
  • To explore the influence of genetic predisposition on self-reported dietary behavior.

Main Methods:

  • Utilized UK Biobank data from 163,619 individuals.
  • Employed linear mixed models to analyze associations.
  • Calculated polygenic scores for various psychiatric disorders.

Main Results:

  • Polygenic scores for ADHD, bipolar disorder, and schizophrenia showed numerous associations with nutrient intake.
  • Autism spectrum disorder polygenic score did not show significant associations.
  • Higher alcohol dependence polygenic score linked to increased alcohol consumption.
  • Higher persistent thinness polygenic score associated with reporting lower food weight.

Conclusions:

  • Polygenic propensity for psychiatric disorders is associated with dietary behavior.
  • Genetic factors may influence specific nutrient intake and eating patterns.
  • Findings highlight the interplay between genetics, mental health, and diet, warranting cautious interpretation due to self-reported data.