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Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

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Allergens in Hand, Foot, and Hand-Foot Eczema: An Intercomparison by Patch Testing.

S Sahana¹, S G Chethana¹, G R Kanthraj¹

¹Department of Dermatology, Venereology and Leprology, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

Indian Journal of Dermatology

|August 27, 2021

Summary

This study found nickel to be the most common allergen in hand, foot, and hand-foot eczema. Multiple and concurrent contact allergies were prevalent, with delayed reactions noted in some patients.

Keywords:

Allergic contact dermatitis hand–foot eczema patch testing

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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

Dermatology
Allergology
Contact Dermatitis Research

Background:

Hand eczema (HE), foot eczema (FE), and hand-foot eczema (HFE) are common skin conditions triggered by various environmental and occupational exposures.
Identifying causative allergens is crucial for effective management and prevention of these eczemas.

Purpose of the Study:

To determine the common allergens responsible for HE, FE, and HFE.
To investigate the prevalence of multiple and concurrent contact allergies in patients with these conditions.

Main Methods:

A study involving 190 patients was conducted between October 2013 and August 2015.
Patch testing was performed on 150 patients to identify allergic triggers.
Statistical analyses included descriptive statistics, Cramer's V, and Chi-square tests.

Main Results:

Hand-foot eczema (HFE) was the most frequent diagnosis (55.8%), followed by hand eczema (HE) and foot eczema (FE) (22.1% each).
Nickel was the most prevalent allergen across all three conditions (41.79%), followed by potassium dichromate.
Multiple contact allergies were identified in 44% of patients, with concurrent reactions, polysensitization, and mixed reactions observed.

Conclusions:

Significant rates of multiple and concurrent contact allergies, including to nickel sulfate, potassium dichromate, and cobalt chloride, were observed.
No distinct allergen patterns were found differentiating HE, FE, and HFE.
A delayed reading of patch tests (after day 7) is recommended for HFE cases.