Related Experiment Video
Updated: Oct 22, 2025
08:36
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
813
Myxedema Psychosis: Systematic Review and Pooled Analysis
Mouhand F H Mohamed1,2, Mohammed Danjuma1,3, Mohammed Mohammed4
1Department of Medicine, Hamad Medical Corporation, Doha, Qatar.
Neuropsychiatric Disease and Treatment
|August 27, 2021
Summary
Myxedema psychosis (MP) involves psychotic symptoms in hypothyroidism patients. Early screening for thyroid dysfunction is crucial, as treatment with thyroxine leads to over 90% recovery in these cases.
Area of Science:
- Endocrinology
- Psychiatry
- Systematic Review
Background:
- Myxedema psychosis (MP) describes psychotic symptoms in untreated hypothyroidism.
- Optimal assessment and treatment strategies for MP remain unclear.
Purpose of the Study:
- To characterize the clinical presentation and management of myxedema psychosis.
- To synthesize existing literature on MP through a systematic review.
Main Methods:
- Systematic review of case reports and observational studies (1980-2019).
- Searched PubMed, Embase, Google Scholar, and Cochrane databases.
- Data synthesis using descriptive and inferential statistics.
Main Results:
- 75 MP cases analyzed; median age 42, 53% undiagnosed hypothyroidism.
- Delusions (91%) and hallucinations (78%) were common; physical signs absent in 26%.
- Thyroxine treatment with antipsychotics yielded >90% recovery; IV therapy showed a trend for shorter psychosis duration.
Conclusions:
- MP presents with diverse psychiatric and physical symptoms.
- Screening for thyroid dysfunction is valuable in first-episode psychosis.
- Further research is needed due to a lack of published data.
More Related Videos
Related Concept Videos
01:20Myasthenia Gravis: Overview and Treatment
2.1K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.1K
01:15Myasthenia Gravis: Diagnostic Tests
1.5K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.5K
01:24Mania and Antimanic Drugs: Overview
376
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
376