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Harnessing immunological targets for COVID-19 immunotherapy

Abhishesh Kumar Mehata1, Matte Kasi Viswanadh1, Vishnu Priya1

  • 1Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU), Varanasi, 221005, India.

Future Virology
|August 27, 2021
PubMed

Insights

Immunotherapy offers a promising avenue for a permanent cure for COVID-19 by harnessing innate immunity. Enhancing T-cell responses and utilizing innate immune cells can lead to long-lasting protection against SARS-CoV-2.

Area of Science:

  • Immunology
  • Virology
  • Infectious Diseases

Background:

  • COVID-19, caused by SARS-CoV-2, is a highly contagious disease.
  • Current vaccines primarily use mRNA encapsulated in liposomes to elicit antibody production.
  • The role of innate immunity in combating viral infections is crucial but underexplored for therapeutic strategies.

Purpose of the Study:

  • To explore the potential of immunotherapy as a permanent cure for COVID-19.
  • To investigate the role of innate immune cells in clearing SARS-CoV-2 infections.
  • To highlight the benefits of harnessing innate immunity for long-lasting COVID-19 protection.

Main Methods:

  • Review of current immunotherapy strategies for viral infections.
  • Analysis of the mechanisms of innate immune cell surveillance and response.
  • Examination of T-cell enhancement principles in antiviral immunity.

Main Results:

  • Immunotherapy presents a significant potential for developing a permanent cure for COVID-19.
  • Innate immune cells play a vital role in detecting and clearing viral infections.
  • Enhancing T-cell and innate immune responses can generate durable protective immunity.

Conclusions:

  • Harnessing innate immunity is a promising strategy for developing effective and long-lasting COVID-19 treatments.
  • Immunotherapy targeting innate immune responses offers new hope for combating SARS-CoV-2.
  • Further research into innate immunity could lead to novel therapeutic approaches for COVID-19.
Keywords:
COVID-19cytokine stormimmunotherapyinnate immunitynovel coronavirus

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