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Increased Expression of Cardiotrophin-1 in Cardiomyopathy Patients

S Sharif1, A Saleem1, S Naz1

  • 1Department of Zoology, Lahore College for Women University, Lahore, Pakistan.

Balkan Journal of Medical Genetics : BJMG
|August 27, 2021
PubMed

Insights

Cardiotrophin-1 (CT-1) levels are significantly elevated in cardiomyopathy (CM) patients. This cardiac dysfunction marker

Area of Science:

  • Cardiology
  • Molecular Biology
  • Genetics

Background:

  • Cardiomyopathy (CM) is a significant cause of mortality.
  • Both genetic and environmental factors contribute to CM.
  • Cardiotrophin-1 (CT-1) plasma levels are linked to CM and affect cardiomyocyte differentiation.

Purpose of the Study:

  • To evaluate the expression of Cardiotrophin-1 (CT-1) in patients with cardiomyopathy (CM).

Main Methods:

  • Study included 40 subjects (20 CM, 20 controls) from January to June 2016.
  • Data collected via questionnaire (age, BMI, CM history).
  • RNA isolated from blood, converted to cDNA, and CT-1 expression analyzed using reverse-transcriptase-polymerase chain reaction (RT-PCR).

Main Results:

  • Mean age of CM subjects was 40.1±6.03 years; controls were 35.0±3.7 years.
  • Mean CT-1 expression was 5.2±0.66 in CM subjects versus 1.00±0.001 in controls.
  • CT-1 expression showed a significant difference in the CM group and correlated with age and BMI.

Conclusions:

  • Cardiotrophin-1 (CT-1) expression is significantly higher in cardiomyopathy patients.
  • CT-1 expression is correlated with age and BMI in individuals with CM.
  • Findings suggest CT-1 as a potential biomarker for cardiomyopathy.

Keywords:
Cardiomyopathy (CM)Cardiotrophin-1 (CT-1)Gene expressionPakistani populationReverse-transcriptase-polymerase chain reaction RT-PCR

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