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Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
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Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

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Potential Strategies to Improve the Effectiveness of Drug Therapy by Changing Factors Related to Tumor

Dehong Cao1, Xiaokaiti Naiyila1,2, Jinze Li1,2

  • 1Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Cell and Developmental Biology
|August 27, 2021
PubMed

Insights

The tumor microenvironment (TME) influences cancer growth and drug resistance. Targeting TME cellular components offers strategies to enhance cancer therapy effectiveness.

Area of Science:

  • Oncology
  • Cancer Biology
  • Immunology

Background:

  • The tumor microenvironment (TME) comprises diverse cellular and extracellular components crucial for tumor progression.
  • The TME significantly impacts tumor occurrence, development, metastasis, and therapeutic outcomes.
  • Tumor cell interactions within the TME can lead to acquired drug resistance.

Purpose of the Study:

  • To review the key cellular components of the tumor microenvironment.
  • To explore strategies for modulating TME factors to improve drug therapy efficacy.

Main Methods:

  • Literature review focusing on cellular components of the TME.
  • Analysis of interactions between tumor cells and the microenvironment.
  • Identification of therapeutic strategies targeting TME components.

Main Results:

  • The TME's cellular composition dictates tumor behavior and treatment response.
  • Specific cellular interactions within the TME contribute to therapeutic resistance.
  • Modulating TME factors presents a promising avenue for overcoming drug resistance.

Conclusions:

  • Understanding the TME's cellular dynamics is critical for effective cancer treatment.
  • Targeting the TME offers a viable strategy to enhance the efficacy of existing and novel cancer therapies.
Keywords:
cancer-associated fibroblastsdrug therapytargeted therapytumor microenvironmenttumor-associated macrophages

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