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Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
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Stem Cell-Derived Exosomes Potential Therapeutic Roles in Cardiovascular Diseases

Selvaraj Jayaraman1, Dhanavathy Gnanasampanthapandian2, Johnson Rajasingh3

  • 1Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

Frontiers in Cardiovascular Medicine
|August 27, 2021
PubMed

Insights

Naturally produced exosomes show promise in cardiac regenerative medicine. These tiny vesicles are cardioprotective, serve as pharmaceutical delivery agents, and can be biomarkers for cardiovascular diseases (CVD).

Area of Science:

  • Cardiovascular Research
  • Regenerative Medicine
  • Nanomedicine

Background:

  • Cardiovascular diseases (CVD) are a leading global cause of death due to myocardial abnormalities.
  • Stem cell therapies are being explored for CVD treatment.
  • Naturally occurring membranous vesicles, known as exosomes, are emerging as key players in cardiac health.

Purpose of the Study:

  • To explore the potential of exosomes in cardiac regenerative medicine.
  • To investigate exosomes as cardioprotective agents and pharmaceutical delivery systems.
  • To highlight the role of exosome-derived microRNAs (miRNAs) as biomarkers for CVD risk assessment.

Main Methods:

  • Investigated exosomes derived from various stem cells.
  • Analyzed the intracellular delivery capabilities of exosomes for proteins and nucleic acids.
  • Examined exosomes, particularly those containing miRNAs, for their diagnostic and therapeutic potential in CVD.

Main Results:

  • Exosomes derived from stem cells demonstrate significant cardioprotective effects.
  • Exosomes function effectively in the intracellular delivery of therapeutic molecules.
  • Exosomes containing miRNAs show promise as reliable biomarkers for CVD risk.

Conclusions:

  • Exosomes represent a promising therapeutic avenue for cardiovascular diseases.
  • Their small size, low immunogenicity, and lack of toxicity make them attractive nanomedicine candidates.
  • Further research into exosome development is crucial for their application as diagnostic and therapeutic tools in medicine.

Keywords:
cardiovascular therapycell therapyexosomesmiRNAstem cells

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