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The application of oncolytic viruses in cancer therapy

Yang Gao1, Yan Wu1, Tian Huan1

  • 1School of Life Sciences, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, People's Republic of China.

Biotechnology Letters
|August 27, 2021
PubMed

Insights

Oncolytic virus therapy engineers viruses to target and destroy cancer cells. This review explores advancements in oncolytic virotherapy for improved tumor treatment and management.

Area of Science:

  • Oncolytic virotherapy
  • Cancer biology
  • Molecular virology

Background:

  • Oncolytic therapy utilizes genetically modified viruses to selectively infect and kill cancer cells.
  • Viruses exploit abnormal cancer cell signaling pathways for replication and tumor lysis.
  • Current research focuses on enhancing oncolytic virus efficacy and safety through biomolecular technology.

Purpose of the Study:

  • To review current progress in oncolytic virus therapy for cancer treatment.
  • To summarize the molecular mechanisms underlying oncolytic virus activity.
  • To discuss advancements in transforming oncolytic viruses for enhanced therapeutic outcomes.

Main Methods:

  • Literature review of clinical studies and biomolecular advancements.
  • Analysis of genetic modification techniques for oncolytic viruses.
  • Examination of molecular mechanisms of viral replication and tumor cell interaction.

Main Results:

  • Oncolytic viruses demonstrate selective replication in tumor cells, leading to cell death.
  • Biomolecular engineering enhances oncolytic virus potency and reduces adverse effects.
  • Significant progress has been made in clinical applications of oncolytic virotherapy.

Conclusions:

  • Oncolytic virus therapy is a promising approach for cancer treatment.
  • Further research into molecular mechanisms will optimize therapeutic strategies.
  • Continued development of biomolecular technologies will improve oncolytic virus efficacy and safety.
Keywords:
Cancer therapyImmune responseMolecular mechanismOncolytic virus

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