[Management of toxicities from immunotherapy]
Deutsche Medizinische Wochenschrift (1946)
|August 27, 2021
Summary
Checkpoint inhibitor immunotherapy, using agents targeting CTLA4 or PD-1/PD-L1, requires managing immune-related adverse events (irAEs). This guide outlines prevention, diagnosis, and treatment strategies for irAEs in cancer patients.
Area of Science:
- Oncology
- Immunology
Background:
- Immunotherapy utilizing checkpoint inhibitors (targeting CTLA4, PD-1, or PD-L1) is a standard cancer treatment.
- Immune-related adverse events (irAEs) are common and can affect any organ system.
- irAEs can manifest early, late, or even after treatment cessation, up to two years post-therapy.
Purpose of the Study:
- To provide a comprehensive overview of managing patients undergoing immunotherapy who experience irAEs.
- To detail the prevention, diagnostic approaches, and treatment modalities for irAEs.
Main Methods:
- Grading of irAEs using Common Terminology Criteria for Adverse Events (CTCAE).
- Treatment strategies encompass local/symptomatic care, corticosteroids, and other immunosuppressants based on severity.
Main Results:
- The article presents a general approach to irAE management.
- It covers the spectrum of irAEs, their timing, and grading.
Conclusions:
- Effective management of irAEs is crucial for continuing immunotherapy.
- A systematic approach to prevention, diagnosis, and treatment optimizes patient outcomes.
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