Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism
Eduardo Pulgar1,2, Cornelia Schwayer3, Néstor Guerrero1,2
1Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Elife
|August 27, 2021
Summary
In zebrafish, incomplete epithelial delamination allows progenitor cells to coordinate movements with surrounding tissues. This mechanism ensures proper cell allocation for organ development.
Area of Science:
- Developmental biology
- Cell biology
- Tissue morphogenesis
Background:
- Progenitor cell migration is crucial for development but poorly understood.
- Mechanisms guiding progenitor cells to differentiation sites remain unclear.
Purpose of the Study:
- To elucidate the developmental strategies of progenitor cell allocation.
- To understand how progenitor cells coordinate movement with adjacent tissues.
Main Methods:
- Investigated progenitor cell delamination in zebrafish laterality organ development.
- Utilized live imaging and cell tracking to observe cell behaviors.
- Analyzed cell-cell contacts and protrusion dynamics during migration.
Main Results:
- Discovered that incomplete epithelial delamination facilitates progenitor cell movement.
- Observed progenitors retaining apical contacts, enabling epithelial layer to guide them.
- Identified protrusion-dependent cell-cell contacts for collective cell migration.
Conclusions:
- Incomplete delamination acts as a platform for coordinated tissue movements.
- This process ensures progenitor cell allocation to the correct differentiation site.
- Reveals a novel mechanism for collective cell migration in development.
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