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Updated: Oct 22, 2025

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Knee osteonecrosis after COVID-19.

María Angulo-Ardoy¹, Álvaro Ureña-Aguilera¹

¹SERMAS, EAP Adelfas, M.P. Avenida Ciudad de Barcelona, Madrid, Spain.

Family Practice

|August 27, 2021

Summary

A COVID-19 survivor developed osteonecrosis, a bone condition, a month after infection. This case highlights the need for careful evaluation of unusual joint pain following SARS-CoV-2 infection.

Area of Science:

Orthopedics
Infectious Diseases
Radiology

Background:

COVID-19 is an emerging infection with unknown long-term complications.
Hypercoagulability is noted in severe cases, but ischemic complications like osteonecrosis are understudied.
Previous SARS-CoV1 studies suggested a link to osteonecrosis, possibly due to corticosteroids or the virus itself.

Observation:

A 78-year-old woman presented with right knee pain and swelling one month post-COVID-19.
Radiography showed no changes, but MRI revealed osteonecrosis of the internal femoral condyle.
Blood tests indicated no coagulation abnormalities.

Findings:

The patient's osteonecrosis was diagnosed via MRI following COVID-19 infection.
No coagulopathy was detected, suggesting a potential direct viral link or other mechanism.

Keywords:

COVID-19 Corticosteroids SARS-CoV1 hypercoagulability joint pain osteonecrosis

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Treatment was conservative due to pandemic-related surgical delays.

Implications:

This case suggests a potential association between COVID-19 and osteonecrosis.
Unusual joint pain after COVID-19 warrants thorough investigation.
Further research is needed to understand the mechanisms and long-term effects of COVID-19 on bone health.