Multiple genome viewer (MGV): a new tool for visualization and comparison of multiple annotated genomes

Area of Science:

• Genomics
• Bioinformatics
• Comparative Genomics

Background:

• Annotated genomes for 16 inbred and 2 wild-derived mouse strains are available.
• These genomic resources are crucial for mouse genetics research and comparative studies.

Purpose of the Study:

• To develop a tool for visualizing, exploring, and comparing genome annotations.
• To facilitate comparative genomics across multiple mouse strains and potentially other organisms.

Main Methods:

• Development of the Multiple Genome Viewer (MGV) web tool.
• MGV displays synchronized, horizontal genome tracks with vertical connectors for homologous features.
• User-customizable feature display based on coordinates, function, phenotype, disease, or pathway.

Main Results:

• MGV enables synchronized navigation (scrolling, zooming) across multiple genomes.
• Users can generate custom gene and feature sets for visualization.
• The tool is genome-agnostic, supporting cross-species comparisons.

Conclusions:

• MGV is a valuable resource for researchers studying mouse genetics and comparative genomics.
• The viewer enhances the exploration and comparison of complex genomic data.
• Its genome-agnostic design offers potential for broader comparative analyses across species.