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Updated: Oct 22, 2025

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
Published on: August 19, 2025
The potential effect of Polypodium leucotomos extract on ultraviolet- and visible light-induced photoaging
Aunna Pourang1, Mohsen Dourra2, Nneamaka Ezekwe1
1Photomedicine and Photobiology Unit, Department of Dermatology, Henry Ford Health System, 3031 W. Grand Blvd, Suite 800, Detroit, MI, 48202, USA.
Abstract:
Photoaging induced by both ultraviolet and visible light has been shown to lead to increased inflammation and dysregulation of the extracellular matrix. Standardized extract of the Polypodium leucotomos fern, PLE, possesses anti-inflammatory and antioxidant properties, and has been shown to potentially mitigate photoaging through various mechanisms. This comprehensive review presents the data available on the effects of P. leucotomos extract on UV and VL-induced photoaging in vitro as well as in vivo in murine and human models.
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